In order to meet the development of all-English or bilingual teaching of organic chemistry in medical colleges of our country, we are now grouped to edit this book. The sequence of chapters and related contents in this book are consistent to the sixth edition of Organic Chemistry in Chinese which is published by People’s Medical Publishing House as a NHO’s programming book material. We have applied “three basic contents—basic theories, basic knowledge, basic skills” and “five features— thoughtful, scientific, advanced, heuristic, adaptable” to this book. That means precise demonstrations, clear arrangements, visual illuminations and fluent language. The whole book is arranged in a proper and gradual sequence to avoid destroying the coherence or connections of chapters and furthermore unnecessary repetition. The organization of this book is by functional group, beginning with the simple (alkanes) and progressing to the more complex. Within this organization, however, there is also an emphasis on explaining the fundamental mechanistic similarities of reactions. The essays at the end of chapters (except chapters 1 and 13) present interesting applications of organic chemistry relevant to the main chapter subject. Including topics from science, biological science, medicine, and day-to-day life, these applications enliven and reinforce the material presented in each chapter. We have contributed our effort to make this book as effective, clear and readable as possible, to show the beauty and logic of organic chemistry; and to make the subject interesting to learn. The authors thank Miss Hu Zhangcheng, Miss Yang Ou and Mr. Wang Xinhua, who are all editors from Huazhong University of Science and Technology Press. Their encouragement, excellent work made it possible to put the final manuscript into book form
作者简介:
章节目录:
Chapter 1 Introduction (1)
1.1 Organic Compounds and Organic Chemistry (1)
1.2 Bonding in Organic Compound (2)
1.3 Attractions between Molecules (10)
1.4 Classification and Reaction Types of Organic Compounds (12)
1.5 Acid-Base Theory (14)
Additional Problems (17)
Chapter 2 The Alkanes and Cycloalkanes (19)
2.1 Alkanes (19)
2.2 Cycloalkanes (35)
Essay:Radical in Biology, Medicine and Industry (47)
Additional Problems (48)
Chapter 3 Alkenes and Alkynes (50)
3.1 Structure of Alkenes and Alkynes (50)
3.2 Nomenclature of Alkenes and Alkynes (52)
3.3 Cis-Trans Isomerism in Alkenes (54)
3.4 Electronic Effect (57)
3.5 Resonance Structure (60)
3.6 Physical Properties of Alkenes and Alkynes (62)
3.7 Chemical Properties of Alkenes and Alkynes (64)
3.8 Conjugated Dienes (76)
Essay:Terpenes—Naturally Occurring Alkenes (78)
Additional Problems (79)
Chapter 4 Aromatic Compounds (82)
4.1 Benzene:Structure and Bonding (82)
4.2 Nomenclature of Aromatic Compounds (84)
4.3 Physical Properties of Aromatic Compounds (85)
4.4 Chemical Properties of Aromatic Compounds (86)
4.5 Fused-Ring Aromatic Hydrocarbons (94)
4.6 Aromaticity — Hückel Rule (96)
Essay:Cancer and Carcinogens (97)
Additional Problems (99)
Chapter 5 Enantiomerism (102)
5.1 Enantiomers (103)
5.2 Measurement of Optical Activity (105)
5.3 Representation of Enantiomer—Fischer Projection Formula (107)
5.4 Nomenclature of Enantiomer (108)
5.5 Stereoisomers with Two Chiral Carbon Atoms (110)
5.6 Enantiomers without Chiral Carbon Atoms (112)
5.7 Enantiomers in Cyclic Compounds (113)
5.8 Properties of Enantiomer (114)
5.9 Resolution of Enantiomers (115)
5.10 Reform of Chiral Molecules and Biological Function (116)
Essay:Stereoisomerism in the Biological World (118)
Additional Problems (119)
Chapter 6 Halohydrocarbons (122)
6.1 Classification and Nomenclature of Halohydrocarbons (122)
6.2 Physical Properties of Halohydrocarbons (124)
6.3 Chemical Properties of Halohydrocarbons (125)
Essay:Naturally Occurring Organohalogen Compounds (137)
Additional Problems (138)
Chapter 7 Alcohols, Phenols, and Ethers (142)
7.1 Alcohols (142)
7.2 Phenols (153)
7.3 Ethers (161)
7.4 Epoxides (164)
7.5 Sulfur Analogues of Alcohols and Ethers:Thiols and Sulfides (168)
Essay:Measuring Blood Alcohol (171)
Addition Problems (172)
Chapter 8 Aldehydes and Ketones (175)
8.1 Classification and Nomenclature of Aldehydes and Ketones (175)
8.2 Structure of Aldehydes and Ketones (177)
8.3 Physical Properties of Aldehydes and Ketones (178)
8.4 Chemical Properties of Aldehydes and Ketones (178)
Essay:Some Biological Nucleophilic Addition Reaction (189)
Addition Problems (190)
Chapter 9 Carboxylic Acids and Substituted Acids (192)
9.1 Carboxylic Acids (192)
9.2 Hydroxy Acids (201)
9.3 Keto-Acids (205)
Essay:Food Preservatives (206)
Additional Problems (207)
Chapter 10 Derivatives of Carboxylic Acids (210)
10.1 Classification and Structure of Carboxylic Acid Derivatives (210)
10.2 Nomenclature of Carboxylic Acid Derivatives (210)
10.3 Physical Properties of Carboxylic Acid Derivatives (213)
10.4 Chemical Properties of Carboxylic Acid Derivatives (213)
10.5 Urea and Barbiturates (220)
Essay:Aspirin and Other Analgesics (222)
Additional Problems (223)
Chapter 11 Amines (226)
11.1 Classification and Nomenclature of Amines (226)
11.2 Structure of Amines (229)
11.3 Physical Properties of Amines (231)
11.4 Chemical Properties of Amines (232)
11.5 Aromatic Diazonium Salts (239)
11.6 Alkaloids (242)
Essay:Local Anesthetics and Cocaine (244)
Additional Problems (245)
Chapter 12 Spectroscopy of Organic Compounds (248)
12.1 General Principle of Absorption Spectra (248)
12.2 Ultraviolet -Visible Spectra (250)
12.3 Infrared Spectra (254)
12.4 Nuclear Magnetic Resonance Spectra (263)
12.5 Mass Spectrometry (275)
Essay: Magnetic Resonance Imaging (277)
Additional Problems (279)
Chapter 13 Heterocycles (281)
13.1 Classification and Nomenclature of Heterocycles (281)
13.2 Structure and Properties of Five-Membered Aromatic Heterocycles (282)
13.3 Structure and Properties of Pyridine and Pyrimidine (286)
13.4 Fused-Heterocyclic Compounds (289)
13.5 The Sulfa Drugs (290)
Additional Problems (291)
Chapter 14 Carbohydrates (294)
14.1 Classification and Nomenclature of Carbohydrates (295)
14.2 Monosaccharides (295)
14.3 Disaccharides and Polysaccharides (305)
Essay:Diabetes and Low-Calorie Sweeteners (309)
Additional Problems (311)
Chapter 15 Lipids (313)
15.1 Fats and Oils—Triacylglycerols (313)
15.2 Waxes (318)
15.3 Phospholipids (319)
15.4 Steroids (323)
15.5 Steroid Hormones (327)
Essay:Errors in the Metabolism of Fatty Acids—Lorenzo’s Oil (329)
Additional Problems (330)
Chapter 16 Amino Acids, Peptides and Proteins (332)
16.1 Amino Acids (332)
16.2 Peptides (342)
16.3 Proteins (347)
Essay:Sickle Cell Anemia—A Biochemical Disease and Mad Cow Disease (355)
Additional Problems (357)
Chapter 17 Nucleic Acids (359)
17.1 The Chemical Structure and Classification of Nucleic Acids (359)
17.2 Nucleosides and Nucleotides (361)
17.3 The Hierarchy of Nucleic Acid Structure (364)
17.4 Physical and Chemical Properties of Nucleic Acids (368)
Essay:The Human Genome Project (368)
Additional Problems (369)
Index (371)